Cystic fibrosis, also known as mucoviscidosis, is a genetically inherited, chronic disease and is progressive in nature. The onset of cystic fibrosis typically occurs in early childhood or, rarely, at birth. The primary symptoms of cystic fibrosis include breathing difficulties, high salt content in the sweat, and secretion of abnormally viscous mucus. The principal indicators of cystic fibrosis in patients are pancreatic insufficiency, pancreatitis, chronic bronchitis, adolescent diabetes, male sterility, and very rarely liver cirrhosis or intestinal obstruction. The most usual forms of cystic fibrosis are those with respiratory complications, difficulties related to digestion, and anomalies in height and growth. The mortality and morbidity of a patient are dependent on the degree of bronchopulmonary involvement.
Significant unmet need remains for Cystic Fibrosis (CF) treatment options that are effective against biofilms and avoid resistance
Mucus build-up in airways causes chronic chest infections
Physical therapies, antibiotics, mucolytics, pancreatic enzymes, CFTR modulators, oxygen therapy and ultimately lung transplant
Major problem with drug-resistant bacteria – increasingly difficult to treat with antibiotics